Carotenoids from cyanobacteria modulate iNOS and inhibit the production of inflammatory mediators: Promising agents for the treatment of inflammatory conditions

• Type: Article in International Scientific Journal
• Date: 2024

Authors

Morone, J (Author) Other; Hentschke, G (Author) Other; Eugenia Pinto (Author) FFUP; Morais, J (Author) Other; Cruz, P (Author) Other; Vitor Vasconcelos (Author) FCUP; Martins, R (Author) Other; Lopes, G (Author) Other

Journal

Title: Algal Research

Vol. 83

ISSN: 2211-9264

Publisher: Elsevier

Indexing

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Other information

Authenticus ID: P-017-4AS

DOI: 10.1016/j.algal.2024.103729

Abstract (EN): Cyanobacteria are green multiproduct refineries of increasing interest for different industrial prospects. In this work, eleven cyanobacteria strains isolated from the Cape Verde archipelago were explored for their biotechnological applications in the field of inflammation. A biorefinery approach was employed to produce carotenoidtargeted extracts, further profiled by HPLC-PDA and explored for their ability to i) scavenge important physiological free radicals of oxygen (superoxide anion radical, O-2(center dot-)) and nitrogen (nitric oxide, (NO)-N-center dot) involved in the inflammatory process ii) slow-down post-inflammatory hyperpigmentation and iii) modulate the activity of inflammatory cytokine-producing enzymes, in enzymatic and cell systems comprising RAW 264.7 cells. The studied strains turned out to be important carotenoid producers (70.47-186.71 mu g mg(-1)dry extract), mainly represented by beta-carotene and zeaxanthin. The targeted-extracts stood-out for their potential to slow-down the inflammatory process through a multitarget approach: scavenging (NO)-N-center dot and O-2(center dot-), reducing inflammatory cytokines production through lipoxygenase inhibition, and modulating the inducible nitric oxide synthase in LPSstimulated RAW 264.7 cells, with strains of the order Nodosilineales revealing to be worth of further biotechnological exploitation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14