Inula viscosa (L.) Aiton Ethanolic Extract Inhibits the Growth of Human AGS and A549 Cancer Cell Lines

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Rechek, H (Author) Other; Haouat, A (Author) Other; Hamaidia, K (Author) Other; Pinto, DCGA (Author) Other; Boudiar, T (Author) Other; Valega, MSGA (Author) Other; David M Pereira (Author) FFUP; Pereira, RB (Author) Other; Silva, AMS (Author) Other

Journal

Title: Chemistry and Biodiversity

Vol. 20

ISSN: 1612-1872

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 0 Citations

Scopus

Other information

Authenticus ID: P-00X-YTP

DOI: 10.1002/cbdv.202200890

Abstract (EN): The present study shows the chemical profile and cytotoxic properties of the ethanolic extracts of Inula viscosa from Northeast Algeria. The extract was obtained by maceration using ethanol. Its phenolic profile was determined using ultra-high-performance liquid chromatography coupled with a diode array detector and an electrospray mass spectrometer (UHPLC-DAD-ESI/MS), which allowed the identification and quantification of 17 compounds, 1,5-O-caffeoylquinic acid being the most abundant. The cytotoxic activity was assessed against human gastric cancer (AGS) and human non-small-cell lung cancer (A549) cell lines, whereas ethanolic extract elicited nearly 60 % and 40 % viability loss toward AGS and A549 cancer cells, respectively. Results also showed that cell death is caspase-independent and confirmed the involvement of RIPK1 and the necroptosis pathway in the toxicity induced by the I. viscosa extract. In addition, the ethanolic extract would not provoke morphological traits in the cancer cells. These findings suggest that I. viscosa can be a source of new antiproliferative drugs or used in preparation plant-derived pharmaceuticals.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13