In vivo behaviour of Bonelike((R))/PLGA hybrid: Histological analysis and peripheral quantitative computed tomography (pQ-CT) evaluation

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Oliveira, JM (Author) Other; Kawai, T (Author) Other; Lopes, MA (Author) FEUP; Ohtsuki, C (Author) Other; Santos, JD (Author) FEUP; Américo Afonso (Author) FMDUP

Journal

Title: Key Engineering Materials

Vol. 254-256

Pages: 565-568

ISSN: 1013-9826

Publisher: Trans Tech Publications Ltd

Indexing

ISI Web of Knowledge - 1 Citation

ISI Web of Science

Scopus - 1 Citation

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

CORDIS: Technological sciences > Engineering > Biomaterial engineering

Other information

Authenticus ID: P-000-CBF

DOI: 10.4028/www.scientific.net/KEM.254-256.565.

Abstract (EN): The present work consisted in assessing the in vivo biological behaviour of novel Bonelike(R)/PLGA hybrid materials through subcutaneous and tibiae implantations for a 4 week period using an animal model. No sign of inflammation was observed as a result of subcutaneous implantation, which reveals that these materials were well-tolerated by the soft tissues. pQ-CT analysis demonstrated that the implanted materials were highly osteointegrated in bone tissue. SEM analysis at bone defect area revealed that Bonelike(R) resorption occurred after 4 weeks of implantation. Although the osteoconductive properties of Bonelike(R) have been reported in literature, the present work allowed to demonstrate that the silane-coupling agent and the PLGA treatments do not significantly modify the biological performance of Bonelike(R). This result is strongly encouraging since Bonelike(R)/PLGA hybrid materials are being developed for bone tissue healing/regeneration purposes with simultaneous delivery of therapeuthic molecules.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4