Identification of doublestranded genomic dna spanning all chromosomes with mutated KRAS and P53 DNA in the serum exosomes of patients with pancreatic cancer

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Kahlert, C (Author) Other; Melo, SA (Author) Other; Protopopov, A (Author) Other; Tang, J (Author) Other; Seth, S (Author) Other; Koch, O (Author) Other; Zhang, J (Author) Other; Weitz, J (Author) Other; Chin, L (Author) Other; Futreal, A (Author) Other; Kalluri, R (Author) Other

Journal

Title: Journal of Biological Chemistry

Vol. 289

Pages: 3869-3875

ISSN: 0021-9258

Publisher: Elsevier

Indexing

Scopus - 632 Citations

Other information

Authenticus ID: P-00T-4KG

DOI: 10.1074/jbc.c113.532267

Abstract (EN): Background: Exosomes are small vesicles in the tumor microenvironment containing nucleic acids and proteins with the capacity to influence cell behavior. Results: Exosomes contain double-stranded genomic DNA. Conclusion: Exosomes have the capacity to carry and transport genomic DNA spanning all chromosomes with KRAS and p53 mutations. Significance: Exosomes can aid in identifying genomic mutations in patients with pancreatic cancer. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..

Language: English

Type (Professor's evaluation): Scientific