Exosomes in cancer: Use them or target them?

• Type: Another Publication in an International Scientific Journal
• Date: 2018

Authors

Bastos, N (Author) Other; Ruivo, CF (Author) Other; da Silva, S (Author) Other; Melo, SA (Author) FMUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Vol. 78

Pages: 13-21

ISSN: 1084-9521

Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

Indexing

ISI Web of Knowledge - 73 Citations

Scopus - 77 Citations

Other information

Authenticus ID: P-00R-A9S

DOI: 10.1016/j.semcdb.2017.08.009

Abstract (EN): Exosomes are small extracellular vesicles with a significant role in most processes associated with cancer. On one hand, exosomes role in the different hallmarks of cancer has been widely described, highlighting the urge to understand the potential to target communication mediated by exosomes as a novel therapeutic approach in cancer. On the other hand, exosomes stability in circulation and tumor-targeting capacity shows their applicability in the delivery of anti-cancer molecules. This review will discuss the dual applicability of exosomes in cancer focusing on their usage for therapy improvement, or their targeting to block their supportive role in tumor progression and response to therapy. We highlight the current developments and the strategies used to enhance the potential of exosomes to become clinical partners in the treatment of cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9