Effect of food on the pharmacokinetic profile of trans-resveratrol

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Vaz Da Silva, M (Author) FMUP; Loureiro, AI (Author) Other; Falcao, A (Author) Other; Nunes, T (Author) Other; Rocha, JF (Author) Other; Fernandes Lopes, C (Author) Other; Soares, E (Author) Other; Wright, L (Author) Other; Almeida, L (Author) Other; soares-da-silva, p (Author) FMUP

Journal

Title: International Journal of Clinical Pharmacology and Therapeutics

Vol. 46

Pages: 564-570

ISSN: 0946-1965

Publisher: Dustri-Verlag Dr. Karl Feistle

Indexing

ISI Web of Knowledge - 89 Citations

Scopus - 102 Citations

Other information

Authenticus ID: P-003-V5R

Abstract (EN): Objective: It has been postulated that trans-resveratrol may act as an antioxidant, cardioprotective, neuroprotective and cancer chemopreventive agent. The objective of this study was to investigate the effect of food oil the bioavailability of trans-resveratrol following oral administration. Material and methods: Single-centre, open-label, randomized, 2-way crossover study oil 24 healthy subjects. The Study consisted of two consecutive treatment periods separated by a washout of 7 clays or more. Oil each of the Study periods subjects were administered a single-close of 400 mg of trans-resveratrol following either a standard high fat content meal or 8 lis of fasting. Results: There was a large interindividual variability in the trans-resveratrol pharmacokinetic parameters. Mean +/- SD maximum plasma concentration (C-max) was 42.2 +/- 36.6 ng/ml in fed and 47.3 +/- 30.0 mg/ml in fasting conditions. Median time to C-max (t(max)) was 2.0 h in fed and 0.5 h in Casting (p < 0.0001). The fed/fasting geometric mean ratio (GMR) and 90% confidence interval (90% CI) were 79.4 and 53.8. 117.0% for C-max, and 106.0 and 86.8, 128.0% for the area under the plasma concentration-time curve (AUC(0-infinity)). The 90% CI for the GMR of AUC(0-infinity) and C-max fall outside the usual bioequivalence acceptance range of 80, 125%, but that of AUC(0-infinity) was close to the bioequivalence standard. Conclusion: The rate of absorption of trans-resveratrol following an oral 400 mg single-dose was significantly delayed by the presence of food, as reflected by C-max and t(max). However, the extent of absorption, as reflected by AUC(-infinity), was not affected in a relevant way.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7