Subcentimetric papillary thyroid carcinoma with extensive lymph node and brain metastasis: case report and review of literature

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Amado, A (Author) Other; Teixeira, E (Author) Other; Canberk, S (Author) Other; Macedo, S (Author) Other; Castro, B (Author) Other; Pereira, H (Author) Other; Varanda, J (Author) Other; Graça, S (Author) Other; Tavares, A (Author) Other; Soares, C (Author) Other; Oliveira, MJ (Author) Other; Oliveira, M (Author) Other; Soares, P (Author) FMUP; Simoes, MS (Author) Other; Póvoa, AA (Author) Other

Journal

Title: Endocrinology, Diabetes and Metabolism Case Reports

Vol. 2023

Publisher: BioScientifica Ltd.

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Z-S0A

DOI: 10.1530/edm-23-0025

Abstract (EN): We report a 61-year-old male patient without personal history of thyroid carcinoma or radiation exposure. In 2011, he presented with a cervical mass whose biopsy diagnosed a papillary thyroid carcinoma (PTC) in a lymph node metastasis (LNM). Total thyroidectomy with lymphadenectomy of central and ipsilateral compartment was performed. Histopathology identified a 2 mm follicular variant of PTC and LNM in 25/25 lymph nodes. The patient was treated with 150 mCi of radioactive iodine (RAI), followed by levothyroxine suppressive therapy. In 2016, a retrotracheal mass was diagnosed, suggesting local recurrence; patient was submitted to surgical excision and RAI therapy (120 mCi). Due to seizures, in 2019, a brain CT was performed that diagnosed brain metastases. The patient underwent debulking of the main lesion. Histopathology analysis confirmed a metastatic lesion with variated morphology: classical PTC and follicular pattern and hobnail and tall cell features. Molecular analysis revealed BRAFV600E in LNM at presentation and BRAFV600E and TERT promoter (TERTp) mutations in the recurrent LNM and brain metastasis. Based upon this experience we review the reported cases of subcentimetric PTC with brain metastases and discuss the molecular progression of the present case.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7