Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Song, M (Author) Other; Jayasekara, H (Author) Other; Pelucchi, C (Author) Other; Rabkin, CS (Author) Other; Johnson, KC (Author) Other; Hu, JF (Author) Other; Palli, D (Author) Other; Ferraroni, M (Author) Other; Liao, LM (Author) Other; Bonzi, R (Author) Other; Zaridze, D (Author) Other; Maximovitch, D (Author) Other; Aragonés, N (Author) Other; Martin, V (Author) Other; Castaño-Vinyals, G (Author) Other; Guevara, M (Author) Other; Tsugane, S (Author) Other; Hamada, GS (Author) Other; Hidaka, A (Author) Other; Negri, E (Author) Other; Ward, MH (Author) Other; Sinha, R (Author) Other; Lagiou, A (Author) Other; Lagiou, P (Author) Other; Boffetta, P (Author) Other; Curado, MP (Author) Other; Lunet N (Author) FMUP; Vioque, J (Author) Other; Zhang, ZF (Author) Other; La Vecchia, C (Author) Other; Camargo, MC (Author) Other

Journal

Title: CANCER CAUSES & CONTROL

Vol. 35

Pages: 727-737

ISSN: 0957-5243

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Z-KB5

DOI: 10.1007/s10552-023-01829-1

Abstract (EN): Background Gastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and quantify the relationship in the Stomach cancer Pooling (StoP) Project consortium.Methods A total of 2,084 cases and 7,102 controls from 11 studies in seven countries were included. Summary odds ratios (ORs) and 95% confidence intervals (CIs) assessing associations of key reproductive factors and menopausal hormone therapy (MHT) with gastric cancer were estimated by pooling study-specific ORs using random-effects meta-analysis.Results A duration of fertility of >= 40 years (vs. < 20), was associated with a 25% lower risk of gastric cancer (OR = 0.75; 95% CI: 0.58-0.96). Compared with never use, ever, 5-9 years and >= 10 years use of MHT in postmenopausal women, showed ORs of 0.73 (95% CI: 0.58-0.92), 0.53 (95% CI: 0.34-0.84) and 0.71 (95% CI: 0.50-1.00), respectively. The associations were generally similar for anatomical and histologic subtypes.Conclusion Our results support the hypothesis that reproductive factors and MHT use may lower the risk of gastric cancer in women, regardless of anatomical or histologic subtypes. Given the variation in hormones over the lifespan, studies should address their effects in premenopausal and postmenopausal women. Furthermore, mechanistic studies may inform potential biological processes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11