Thrombosis and cachexia in cancer: Two partners in crime?

• Type: Another Publication in an International Scientific Journal
• Date: 2023

Authors

Liz-Pimenta, J (Author) Other; Tavares, V (Author) Other; Neto, BV (Author) Other; Santos, JMO (Author) Other; Guedes, CB (Author) Other; Araujo, A (Author) Other; Khorana, AA (Author) Other; Rui Medeiros (Author) ICBAS

Journal

Title: Critical Reviews in Oncology/Hematology

Vol. 186

ISSN: 1040-8428

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00Y-9GV

DOI: 10.1016/j.critrevonc.2023.103989

Abstract (EN): Among cancer patients, thrombosis and cachexia are major causes of morbidity and mortality. Although the two may occur together, little is known about their possible relationship. Thus, a literature review was conducted by screening the databases PubMed, Scopus, SciELO, Medline and Web of Science. To summarize, cancer-associated thrombosis (CAT) and cancer-associated cachexia (CAC) seem to share several patient-, tumour- and treatmentrelated risk factors. Inflammation alongside metabolic and endocrine derangement is the potential missing link between CAT, CAC and cancer. Many key players, including specific pro-inflammatory cytokines, immune cells and hormones, appear to be implicated in both thrombosis and cachexia, representing attractive predictive markers and potential therapeutic targets. Altogether, the current evidence suggests a link between CAT and CAC, however, epidemiological studies are required to explore this potential relationship. Given the high incidence and negative impact of both diseases, further studies are needed for the better management of cancer patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15