Next-Generation Sequencing (NGS) in lung cancer care: Advantages, applications, and challenges

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Machado JC (Author) FMUP

Journal

Title: Revista do Grupo de Estudos do Cancro do Pulmão

Vol. 20

ISSN: 1645-9466

Other information

Authenticus ID: P-010-NS4

DOI: 10.32932/gecp.2023.12.047

Abstract (EN): <jats:p>Lung cancer, a prevalent and lethal malignancy, has witnessed significant therapeutic strides driven by the identification and application of predictive biomarkers. These biomarkers, such as EGFR mutations and ALK rearrangements, guide treatment decisions and improve patient outcomes. The advent of Next-Generation Sequencing (NGS) has revolutionized lung cancer diagnostics and treatment by enabling comprehensive genomic profiling. NGS, a high- -throughput sequencing technology, stands out by simultaneously analyzing multiple genes and addressing the genetic diversity inherent in lung tumors. This article explores the transformative role of NGS in lung cancer, emphasizing its applications in personalized treatment strategies, early detection, immunotherapy selection, and disease monitoring through liquid biopsies. Despite challenges, NGS emerges as a beacon of hope, propelling precision oncology and promising improved patient outcomes. This article underscores the impact of NGS in reshaping the landscape of lung cancer care, guiding therapeutic decisions, and advancing scientific understanding.</jats:p>

Language: English

Type (Professor's evaluation): Scientific