Liquefying Flavonoids with Terpenoids through Deep Eutectic Solvent Formation

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Teixeira, G (Author) Other; Abranches, DO (Author) Other; Silva, LP (Author) Other; Vilas-Boas, SM (Author) Other; Pinho, SP (Author) Other; Ana I M C L Lobo Ferreira (Author) FCUP; Luis M N B F Santos (Author) FCUP; Ferreira, O (Author) Other; Coutinho, JAP (Author) Other

Journal

Title: Molecules

Serial No. 3 Vol. 27 No. 969

Final page: 2649

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 5 Citations

Scopus

Other information

Authenticus ID: P-00W-J7G

DOI: 10.3390/molecules27092649

Abstract (EN): The formation of deep eutectic solvents (DES) is tied to negative deviations to ideality caused by the establishment of stronger interactions in the mixture than in the pure DES precursors. This work tested thymol and menthol as hydrogen bond donors when combined with different flavonoids. Negative deviations from ideality were observed upon mixing thymol with either flavone or flavanone, two parent flavonoids that only have hydrogen bond acceptor (HBA) groups, thus forming non-ionic DES (Type V). On the other hand, the menthol systems with the same compounds generally showed positive deviations from ideality. That was also the case with the mixtures containing the more complex hydroxylated flavonoid, hesperetin, which resulted in positive deviations when mixed with either thymol or menthol. COSMO-RS successfully predicted the behavior of the solid-liquid phase diagram of the studied systems, allowing for evaluation of the impact of the different contributions to the intermolecular interactions, and proving to be a good tool for the design of DES.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12