The link between obesity and the gut microbiota and immune system in early-life

• Type: Article in International Scientific Journal
• Date: 2024

Authors

Magalhães M.I. (Author) Other; Azevedo M.J. (Author) Other; Castro F. (Author) Other; Oliveira M.J. (Author) Other; Costa Â.M. (Author) Other; Benedita Sampaio-Maia (Author) FMDUP

Journal

Title: Critical Reviews in Microbiology

Pages: 1-21

ISSN: 1040-841X

Publisher: Taylor & Francis

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-010-B1X

DOI: 10.1080/1040841x.2024.2342427

Abstract (EN): In early-life, the gut microbiota is highly modifiable, being modulated by external factors such as maternal microbiota, mode of delivery, and feeding strategies. The composition of the child¿s gut microbiota will deeply impact the development and maturation of its immune system, with consequences for future health. As one of the main sources of microorganisms to the child, the mother represents a crucial factor in the establishment of early-life microbiota, impacting the infant¿s wellbeing. Recent studies have proposed that dysbiotic maternal gut microbiota could be transmitted to the offspring, influencing the development of its immunity, and leading to the development of diseases such as obesity. This paper aims to review recent findings in gut microbiota and immune system interaction in early-life, highlighting the benefits of a balanced gut microbiota in the regulation of the immune system.

Language: English

Type (Professor's evaluation): Scientific