Histological effects of iron accumulation on mice liver and spleen after administration of a metallic solution

• Type: Article in International Scientific Journal
• Date: 1999

Authors

Pereira, MC (Author) FEUP; Pereira, ML (Author) Other; Sousa, JP (Author) Other

Journal

Title: Biomaterials

Vol. 20

Pages: 2193-2198

ISSN: 0142-9612

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 21 Citations

ISI Web of Science

Scopus - 22 Citations

COMPENDEX

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

Other information

Authenticus ID: P-001-2WN

DOI: 10.1016/s0142-9612(99)00124-6

Abstract (EN): Special attention has been focused on the toxicity of some metallic species released from implanted materials, which accumulate in vital organs over long periods of time. A set of experiments with mice was designed to investigate the individual effects caused by iron in the liver and spleen. Histological features of these organs were evaluated and slight morphological changes were observed during the treatment time suggesting a negative correlation with the duration of the iron treatment. In addition, to associate the histological changes in the organs with iron accumulation an electrochemical method, adsorptive stripping voltammetry, was chosen to quantify the iron levels in these mentioned organs. The accuracy of the proposed method was checked by atomic absorption spectrometry. Both organs showed elevated concentrations of iron, nearly twofold, 7 days after iron administration compared to control organs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6