Peripheral vasculopathy in Raynaud phenomenon: Vascular disease biomarkers

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Silva, I (Author) Other; teixeira, a (Author) Other; Oliveira, J (Author) Other; Almeida, R (Author) Other; Vasconcelos, C (Author) Other

Journal

Title: Angiologia e Cirurgia Vascular

Vol. 12

Pages: 77-84

ISSN: 1646-706X

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-00M-PPD

DOI: 10.1016/j.ancv.2016.02.004

Abstract (EN): Background Introduction: Raynaud's phenomenon (RP) is a well-defined clinical syndrome. Systemic sclerosis (SSc) is the most frequent associated disease to RP (96%). The aim of this study was to assess the differences between primary RP (PRP) and secondary RP (SRP) regarding macrovascular disease parameters, endothelial dysfunction and angiogenesis biomarkers. Materials and methods Flow-mediated dilatation (FMD), endothelin-1 (ET-1), asymmetric dimethylarginine (ADMA) vascular endothelial growth factor (VEGF), endoglin and endostatin were analyzed in a cohort study of 32 PRP patients and 77 SRP all with SSc. 38 of the SRP SSc-associated patients had severe digital ulcer (DU). Results Patients with PRP had significantly longer history of RP compared to SRP SSc-sssociated patients (p = 0.028). FMD was significantly lower in SRP patients 10.85 ± 11.0% (p < 0.001), more evidenced in SRP SSc-associated DU patients 5.34 ± 7.49 (p < 0.001). ET-1 plasma levels were significantly increased in both PRP 7.53 (0.16-11.73) and SRP patients 11.85 (7.42-17.23) (p < 0.001). Significant increased serum levels of ADMA 0.52 (0.45-0.63) ¿mol/L (p < 0.001) and endoglin 3.01 (1.46-7.02) mg/ml (p < 0.001) were found in the SRP SSc-associated group with DU. VEGF was significantly decreased in the DU group 245.06 (158.68-347.33) pg/ml compared to PRP 438.50 (269.26-854.00) pg/ml and SRP naïve-DU patients 290 (166.71-361.78) pg/ml patients (p < 0.001). No significant differences were found between groups regarding endostatin (p = 0.118). Comparing PRP and SRP SSc-associated patients without DU no statistically significant difference regarding FMD, ET-1, ADMA, VEGF, plasma levels were observed. Conclusion Overproduction of ET-1 and VEGF is present in PRP patients. Macrovascular disease and an impaired response to shear stress are more characteristic of SRP with a grater expression in patients with peripheral ischemic lesions. © 2016 Sociedade Portuguesa de Angiologia e Cirurgia Vascular.

Language: English

Type (Professor's evaluation): Scientific