Targeting Glycosylation: A New Road for Cancer Drug Discovery

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Costa, AF (Author) Other; Campos, D (Author) Other; Celso Reis (Author) ICBAS; Gomes, C (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: TRENDS IN CANCER

Vol. 6

Pages: 757-766

ISSN: 2405-8033

Publisher: CELL PRESS

Indexing

ISI Web of Knowledge - 60 Citations

Scopus - 65 Citations

Other information

Authenticus ID: P-00S-1X3

DOI: 10.1016/j.trecan.2020.04.002

Abstract (EN): Cancer is a deadly disease that encompasses numerous cellular modifications. Among them, alterations in glycosylation are a proven reliable hallmark of cancer, with most biomarkers used in the clinic detecting cancer-associated glycans. Despite their clear potential as therapy targets, glycans have been overlooked in drug discovery strategies. The complexity associated with the glycosylation process, and lack of specific methodologies to study it, have long hampered progress. However, recent advances in new methodologies, such as glycoengineering of cells and high-throughput screening (HTS), have opened new avenues of discovery. We envision that glycan-based targeting has the potential to start a new era of cancer therapy. In this article, we discuss the promise of cancer-associated glycosylation for the discovery of effective cancer drugs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10