Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging - from theory to practice

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Luis, C (Author) Other; Maduro, AT (Author) Other; Pereira, P (Author) Other; Mendes, JJ (Author) Other; soares, r (Author) FMUP; Ramalho, R (Author) Other

Journal

Title: Frontiers in Nutrition

Vol. 9

ISSN: 2296-861X

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge - 0 Citations

Scopus

Other information

Authenticus ID: P-00X-8AP

DOI: 10.3389/fnut.2022.958563

Abstract (EN): Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced response to vaccine regimens. The loss of capacity for cell regeneration and the surrounding tissue microenvironment itself is conditioned by genetic, metabolic, and even environmental factors, such as nutrition. The senescence of the immune system (immunosenescence) represents a challenge, especially when associated with the presence of age-related chronic inflammation (inflammaging) and affecting the metabolic programming of immune cells (immunometabolism). These aspects are linked to poorer health outcomes and therefore present an opportunity for host-directed interventions aimed at both eliminating senescent cells and curbing the underlying inflammation. Senotherapeutics are a class of drugs and natural products that delay, prevent, or reverse the senescence process - senolytics; or inhibit senescence-associated secretory phenotype - senomorphics. Natural senotherapeutics from food sources - nutritional senotherapeutics - may constitute an interesting way to achieve better age-associated outcomes through personalized nutrition. In this sense, the authors present herein a framework of nutritional senotherapeutics as an intervention targeting immunosenescence and immunometabolism, identifying research gaps in this area, and gathering information on concluded and ongoing clinical trials on this subject. Also, we present future directions and ideation for future clinical possibilities in this field.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15