Evaluation of BPA and Bis-GMA Release from Recent Dental Composite Materials by LC-MS/MS

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Lopes Rocha, L (Author) Other; Goncalves, VMF (Author) Other; Cunha, SC (Author) Other; Fernandes, JO (Author) FFUP; Pinho, T (Author) Other; M E Tiritan (Author) FFUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: SEPARATIONS

Vol. 20

Final page: 455

ISSN: 2297-8739

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 1 Citation

Other information

Authenticus ID: P-00Z-092

DOI: 10.3390/separations10080455

Abstract (EN): Bisphenol-A (BPA) is a xenoestrogen widely used as a synthetic precursor of resin monomers. There is arise need to acquire BPA-free resin-matrix composites to prevent the health effects of BPA. Six composites with distinctive manufacturer specifications were considered to evaluate the degree of release of BPA and bisphenol A-Diglycidyl Methacrylate (Bis-GMA) in a dental composite. The light-cured resin-matrix specimens (n = 5 for each composite type) were incubated at 37 ? in 1 mL of a 75% ethanol-water solution in a sealed amber glass vial for 7 days. The 75% ethanol-water solution was replaced daily and immediately frozen (-20 ?) until liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. BPA was not detected in any studied resin-based materials. However, Bis-GMA was detected in almost all the studied samples during the experiment, except AF and BF. The highest Bis-GMA concentration was released from ED at 67.43 ng/mL, followed by BE, FS, and NC with 40.75 ng/mL, 8.30 ng/mL, and 0.94 ng/mL, respectively. There is a clear need for more precise and standardized analytical methods to assess the short- and long-term release of resin-based materials. Furthermore, manufacturers should be obliged to provide complete details of the chemical composition of dental products and to promote the development of materials without estrogenic potential.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14