Acute Megakaryoblastic Leukemia With a Four-Way Variant Translocation Originating the RBM15-MKL1 Fusion Gene

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Torres, L (Author) Other; Lisboa, S (Author) Other; Vieira, J (Author) Other; cerveira, n (Author) Other; Santos, J (Author) Other; Pinheiro, M (Author) Other; Correia, C (Author) Other; Bizarro, S (Author) Other; Almeida, M (Author) Other; Manuel R Teixeira (Author) ICBAS

Journal

The Journal is awaiting validation by the Administrative Services.

Title: PEDIATRIC BLOOD & CANCER

Vol. 56

Pages: 846-849

ISSN: 1545-5009

Publisher: Wiley

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-002-S9G

DOI: 10.1002/pbc.22765

Abstract (EN): Acute megakaryoblastic leukemia (AMKL) with t(1;22)(p13;q13) is a subset of acute myeloid leukemia (AML) representing < 1% of all cases and about 70% of pediatric AMKL in the first year of life. We present a case of a 7-month-old female in whom the bone marrow karyotype showed the derivative chromosome der(22)t(1;22)(p13;q13). The RBM15-MKL1 fusion transcript was detected by RT-PCR and confirmed by sequencing analyses. FISH analyses revealed the presence of the four-way translocation t(1;22;17;18)(p13;q13;q22;q12). Pediatr Blood Cancer. 2011;56:846-849. (c) 2011 Wiley-Liss, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4