Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Khankari, NK (Author) Other; Murff, HJ (Author) Other; Zeng, C (Author) Other; Wen, W (Author) Other; Eeles, RA (Author) Other; Easton, DF (Author) Other; Kote Jarai, Z (Author) Other; Al Olama, AA (Author) Other; Benlloch, S (Author) Other; Muir, K (Author) Other; Giles, GG (Author) Other; Wiklund, F (Author) Other; Gronberg, H (Author) Other; Haiman, CA (Author) Other; Schleutker, J (Author) Other; Nordestgaard, BG (Author) Other; Travis, RC (Author) Other; Donovan, JL (Author) Other; Pashayan, N (Author) Other; Khaw, KT (Author) Other; Stanford, JL (Author) Other; Blot, WJ (Author) Other; Thibodeau, SN (Author) Other; Maier, C (Author) Other; Kibel, AS (Author) Other; Cybulski, C (Author) Other; Cannon Albright, L (Author) Other; Brenner, H (Author) Other; Park, J (Author) Other; Kaneva, R (Author) Other; Batra, J (Author) Other; Manuel R Teixeira (Author) ICBAS; Pandha, H (Author) Other; Zheng, W (Author) Other

Journal

Title: British Journal of Cancer

Vol. 115

Pages: 624-631

ISSN: 0007-0920

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 21 Citations

Scopus - 21 Citations

Other information

Authenticus ID: P-00K-VY1

DOI: 10.1038/bjc.2016.228

Abstract (EN): Background: Prostate cancer is a common cancer worldwide with no established modifiable lifestyle factors to guide prevention. The associations between polyunsaturated fatty acids (PUFAs) and prostate cancer risk have been inconsistent. Using Mendelian randomisation, we evaluated associations between PUFAs and prostate cancer risk. Methods: We used individual-level data from a consortium of 22 721 cases and 23 034 controls of European ancestry. Externally-weighted PUFA-specific polygenic risk scores (wPRSs), with explanatory variation ranging from 0.65 to 33.07%, were constructed and used to evaluate associations with prostate cancer risk per one standard deviation (s.d.) increase in genetically-predicted plasma PUFA levels using multivariable-adjusted unconditional logistic regression. Results: No overall association was observed between the genetically-predicted PUFAs evaluated in this study and prostate cancer risk. However, risk reductions were observed for short-chain PUFAs, linoleic (ORLA = 0.95, 95% CI = 0.92, 0.98) and a-linolenic acids (ORALA = 0.96, 95% CI = 0.93, 0.98), among men <62 years; whereas increased risk was found among men >= 62 years for LA (ORLA = 1.04, 95% CI = 1.01, 1.07). For long-chain PUFAs (i.e., arachidonic, eicosapentaenoic, and docosapentaenoic acids), increased risks were observed among men <62 years (ORAA = 1.05, 95% CI = 1.02, 1.08; OREPA = 1.04, 95% CI = 1.01, 1.06; ORDPA = 1.05, 95% CI = 1.02, 1.08). Conclusion: Results from this study suggest that circulating omega-3 and omega-6 PUFAs may have a different role in the aetiology of earlyand late-onset prostate cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8