Relative 8q Gain Predicts Disease-Specific Survival Irrespective of the TMPRSS2-ERG Fusion Status in Diagnostic Biopsies of Prostate Cancer

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Barros Silva, JD (Author) Other; Ribeiro, FR (Author) Other; Rodrigues, A (Author) Other; Cruz, R (Author) Other; Martins, AT (Author) Other; Carmen Jeronimo (Author) ICBAS; henrique, rmf (Author) ICBAS; Manuel R Teixeira (Author) ICBAS

Journal

Title: Genes Chromosomes and Cancer

Vol. 50

Pages: 662-671

ISSN: 1045-2257

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 25 Citations

Other information

Authenticus ID: P-002-PHM

DOI: 10.1002/gcc.20888

Abstract (EN): Screening tools have greatly improved prostate cancer (PCa) detection, but the disease course is heterogeneous, and standard clinicopathological parameters do not fully discriminate aggressive from indolent tumors. To evaluate the prognostic value of the TMPRSS2-ERG fusion gene combined with chromosome arm 8q relative gain in diagnostic biopsies of PCa, we studied a consecutive series of 200 diagnostic needle biopsies from patients with 10-year disease-specific survival data. TMPRSS2-ERG fusion gene status and relative 8q gain were assessed by fluorescent in situ hybridization in whole formalin fixed paraffin-embedded biopsies. The TMPRSS2-ERG fusion gene was detected in 43.5% of PCa and was associated with lower Gleason score (P = 0.045), whereas relative 8q gain was present in 48% of PCa and was associated in high-Gleason score (P < 0.001). ERG rearrangement alone was not associated with clinical outcome, whereas relative 8q gain predicted worse disease-specific survival in PCa patients both with and without the TMPRSS2-ERG fusion gene (P < 0.001), independently of Gleason score, clinical stage, and treatment modality. We conclude that relative 8q gain in diagnostic needle biopsies is a poor prognostic factor independent of the TMPRSS2-ERG fusion gene status and of standard clinicopathological parameters. (C) 2011 Wiley-Liss, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10