Evaluation of Innate Immunity Biomarkers on Admission and at Discharge From an Acute Heart Failure Episode

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Silva, N (Author) Other; Patricio, E (Author) Other; Bettencourt P (Author) FMUP; guimaraes, jt (Author) FMUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: JOURNAL OF CLINICAL LABORATORY ANALYSIS

Vol. 30

Pages: 1183-1190

ISSN: 0887-8013

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Other information

Authenticus ID: P-00M-78J

DOI: 10.1002/jcla.22001

Abstract (EN): BackgroundThe involvement of the immune system in heart failure (HF) has been demonstrated. Evidence shows that innate immunity can have a role in the remodeling process and progression of HF. With previous studies showing the prognostic value of some innate immunity markers and their relevance in this condition, we aim to evaluate how these markers vary on hospitalization due to an acute episode of HF and at discharge. MethodsAbout 154 patients admitted with acute HF were prospectively recruited. Patients were evaluated on admission and at discharge from the hospital. Patients with infection were separately analyzed. Innate immunity, inflammatory, and cardiac biomarkers were measured and were compared between groups and between admission and discharge and with reference values of biological variation. ResultsMedian patients' age was 78 years, and half of the patients were men. The median duration of hospitalization was 6 days. C3 and C4 protein levels significantly increased (P < 0.001) between admission and discharge, as well as eosinophils (P < 0.001) and BNP levels decreased (P < 0.001). Variation in all these variables was independent of infection and biological variation. ConclusionOur results show that innate immunity markers such as C3 and C4 increase after treatment for acute HF, supporting the hypothesis that they can be involved in the resolution of the acute episode.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8