Adherence to inhaled corticosteroids and long-acting ß2-agonists in asthma: A MASK-air study

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Sousa Pinto, B (Author) FMUP; Louis, R (Author) Other; Anto, JM (Author) Other; Amaral, R (Author) FMUP; Sá Sousa, A (Author) Other; Czarlewski, W (Author) Other; Brussino, L (Author) Other; Canonica, GW (Author) Other; Chaves Loureiro, C (Author) Other; Cruz, AA (Author) Other; Gemicioglu, B (Author) Other; Haahtela, T (Author) Other; Kupczyk, M (Author) Other; Kvedariene, V (Author) Other; Larenas Linnemann, DE (Author) Other; Okamoto, Y (Author) Other; Ollert, M (Author) Other; Pfaar, O (Author) Other; Pham Thi, N (Author) Other; Puggioni, F (Author) Other; Regateiro, FS (Author) Other; Romantowski, J (Author) Other; Sastre, J (Author) Other; Scichilone, N (Author) Other; Taborda Barata, L (Author) Other; Ventura, MT (Author) Other; Agache, I (Author) Other; Bedbrook, A (Author) Other; Becker, S (Author) Other; Bergmann, KC (Author) Other; Bosnic Anticevich, S (Author) Other; Bonini, M (Author) Other; Boulet, L (Author) Other; Brusselle, G (Author) Other; Buhl, R (Author) Other; Cecchi, L (Author) Other; Charpin, D (Author) Other; de Blay, F (Author) Other; Del Giacco, S (Author) Other; Ivancevich, JC (Author) Other; Jutel, M (Author) Other; Klimek, L (Author) Other; Kraxner, H (Author) Other; Kuna, P (Author) Other; Laune, D (Author) Other; Makela, M (Author) Other; Morais Almeida, M (Author) Other; Nadif, R (Author) Other; Niedoszytko, M (Author) Other; Papadopoulos, NG (Author) Other; Papi, A (Author) Other; Patella, V (Author) Other; Pétré, B (Author) Other; Rivero Yeverino, D (Author) Other; Robalo Cordeiro, C (Author) Other; Roche, N (Author) Other; Rouadi, PW (Author) Other; Samolinski, B (Author) Other; Savouré, M (Author) Other; Shamji, MH (Author) Other; Sheikh, A (Author) Other; Suppli Ulrik, C (Author) Other; Usmani, OS (Author) Other; Valiulis, A (Author) Other; Yorgancioglu, A (Author) Other; Zuberbier, T (Author) Other; Fonseca, J (Author) FMUP; Costa, EM (Author) Other; Bousquet, J (Author) Other

Journal

Title: Pulmonology

ISSN: 2531-0429

Publisher: Taylor & Francis

Indexing

Scopus - 9 Citations

Other information

Authenticus ID: P-00Y-T6P

DOI: 10.1016/j.pulmoe.2023.07.004

Abstract (EN): Introduction: Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence. We aimed to assess the adherence to inhaled corticosteroids+long-acting ß2-agonists (ICS+LABA) in users of the MASK-air® app, comparing the adherence to ICS+formoterol (ICS+F) with that to ICS+other LABA. Materials and methods: We analysed complete weeks of MASK-air® data (2015-2022; 27 countries) from patients with self-reported asthma and ICS+LABA use. We compared patients reporting ICS+F versus ICS+other LABA on adherence levels, symptoms and symptom-medication scores. We built regression models to assess whether adherence to ICS+LABA was associated with asthma control or short-acting beta-agonist (SABA) use. Sensitivity analyses were performed considering the weeks with no more than one missing day. Results: In 2598 ICS+LABA users, 621 (23.9%) reported 4824 complete weeks and 866 (33.3%) reported weeks with at most one missing day. Higher adherence (use of medication ¿80% of weekly days) was observed for ICS+other LABA (75.1%) when compared to ICS+F (59.3%), despite both groups displaying similar asthma control and work productivity. The ICS+other LABA group was associated with more days of SABA use than the ICS+F group (median=71.4% versus 57.1% days). Each additional weekly day of ICS+F use was associated with a 4.1% less risk in weekly SABA use (95%CI=-6.5;-1.6%;p=0.001). For ICS+other LABA, the percentage was 8.2 (95%CI=-11.6;-5.0%;p<0.001). Conclusions: In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control. © 2023 Sociedade Portuguesa de Pneumologia

Language: English

Type (Professor's evaluation): Scientific