The role of O-glycosylation in human disease

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Magalhães, A (Author) Other; Duarte, HO (Author) Other; Celso Reis (Author) ICBAS

Journal

Title: Molecular Aspects of Medicine

ISSN: 0098-2997

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 10 Citations

Other information

Authenticus ID: P-00T-QE2

DOI: 10.1016/j.mam.2021.100964

Abstract (EN): O-glycosylation is a highly frequent post-translation modification of proteins, with important functional implications in both physiological and disease contexts. The biosynthesis of O-glycans depends on several layers of regulation of the cellular glycosylation machinery, being organ-, tissue- and cell-specific. This review provides insights on the molecular mechanism underlying O-glycan biosynthesis and modification, and highlights illustrative examples of diseases that are triggered or modulated by aberrant cellular O-glycosylation. Particular relevance is given to genetic disorders of glycosylation, infectious diseases and cancer. Finally, we address the potential of O-glycans and their biosynthetic pathways as targets for novel therapeutic strategies. © 2021 Elsevier Ltd

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10