Impact of adiposity on staging and prognosis of colorectal cancer

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Silva, A (Author) Other; Faria, Gil (Author) FMUP; Araujo, A (Author) Other; Monteiro, M (Author) ICBAS

Journal

Title: Critical Reviews in Oncology/Hematology

Vol. 145

ISSN: 1040-8428

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-00R-GFV

DOI: 10.1016/j.critrevonc.2019.102857

Abstract (EN): Abdominal visceral fat is a well-recognized a risk for colorectal cancer (CRC). In contrast to the risk for CRC, the impact of adiposity in disease staging and patient survival is less well-established. Our aim was to critically review the literature on the influence of adiposity assessed by different methods routinely used in clinical settings, on CRC staging and prognosis. In the 32 studies reviewed, overweight was initially identified as a survival advantage, an evidence that was later challenged by studies suggesting that body adiposity is likely to have a deleterious effect in CRC outcomes, particularly in males. Hence, whether obesity has a negative impact in CRC staging or prognosis remains controversial. In sum, addressing the impact of body fat in CRC biological behavior is still an unmet need. Understanding how adiposity influences CRC staging and prognosis could allow further patient risk stratification for devising targeted interventions and improve clinical outcomes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12