Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Carreira, MC (Author) Other; Andrade, S (Author) Other; Gonzalez Izquierdo, A (Author) Other; Amil, M (Author) Other; Folgueira, C (Author) Other; Monteiro, M (Author) ICBAS; Sanz, E (Author) Other; Crujeiras, AB (Author) Other; Casanueva, FF (Author) Other

Journal

Title: Scientific Reports

Vol. 8

ISSN: 2045-2322

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 5 Citations

Other information

Authenticus ID: P-00P-X4K

DOI: 10.1038/s41598-018-34840-7

Abstract (EN): The incidence of obesity has been increasing dramatically worldwide over the past decades, thus requiring novel and effective therapeutic approaches. OBEX is an oral nutritional supplement composed of antioxidants with antiobesity activity. The effects of OBEX have been tested in vivo and in vitro. In vivo, OBEX reduces weight gain by decreasing adiposity gain and increasing energy expenditure in high fat diet-fed mice through the activation of thermogenesis in brown adipose tissue (BAT) independent of eating behaviors. In vitro analysis with 3T3-F442A cells revealed anti-proliferative and anti-differentiation effects of OBEX. In addition, OBEX induced a clear reduction of the lipid load in mature adipocytes obtained from 3T3-F442A cells. Overall, our findings suggest that OBEX has a protective effect against an obesogenic environment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10