The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Iva Fernandes (Author) FCUP; Joana Oliveira (Author) FCUP; Pinho, A (Author) Other; Carvalho, E (Author) Other

Journal

Title: Metabolites

Vol. 22

Final page: 184

ISSN: 2218-1989

Publisher: MDPI

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 19 Citations

Other information

Authenticus ID: P-00W-6S0

DOI: 10.3390/metabo12020184

Abstract (EN): Research in pharmacological therapy has led to the availability of many antidiabetic agents. New recommendations for precision medicine and particularly precision nutrition may greatly contribute to the control and especially to the prevention of diabetes. This scenario greatly encourages the search for novel non-pharmaceutical molecules. In line with this, the daily and long-term consumption of diets rich in phenolic compounds, together with a healthy lifestyle, may have a protective role against the development of type 2 diabetes. In the framework of the described studies, there is clear evidence that the bio accessibility, bioavailability, and the gut microbiota are indeed affected by: the way phenolic compounds are consumed (acutely or chronically; as pure compounds, extracts, or in-side a whole meal) and the amount and the type of phenolic compounds (ex-tractable or non-extractable/macromolecular antioxidants, including non-bioavailable polyphenols and plant matrix complexed structures). In this review, we report possible effects of important, commonly consumed, phenolic-based nutraceuticals in pre-clinical and clinical diabetes studies. We highlight their mechanisms of action and their potential effects in health promotion. Translation of this nutraceutical-based approach still requires more and larger clinical trials for better elucidation of the mechanism of action toward clinical applications.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 28