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Pharmacokinetics of Anidulafungin in Critically Ill Patients with Candidemia/Invasive Candidiasis

Title
Pharmacokinetics of Anidulafungin in Critically Ill Patients with Candidemia/Invasive Candidiasis
Type
Article in International Scientific Journal
Year
2013
Authors
Liu, P
(Author)
Other
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Ruhnke, M
(Author)
Other
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Meersseman, W
(Author)
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Paiva, J-A
(Author)
FMUP
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Kantecki, M
(Author)
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Damle, B
(Author)
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Journal
Vol. 57
Pages: 1672-1676
ISSN: 0066-4804
Other information
Authenticus ID: P-005-2BR
Abstract (EN): The pharmacokinetics of intravenous anidulafungin in adult intensive care unit (ICU) patients were assessed in this study and compared with historical data from a general patient population and healthy subjects. Intensive plasma sampling was performed over a dosing interval at steady state from 21 ICU patients with candidemia/invasive candidiasis. All patients received the recommended dosing regimen (a 200-mg loading dose on day 1, followed by a daily 100-mg maintenance dose), except for a 54-year-old 240-kg female patient (who received a daily 150-mg maintenance dose instead). Plasma samples were assayed for anidulafungin using a validated liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters in ICU patients were calculated by a noncompartmental method. With the exclusion of the 240-kg patient, the median (minimum, maximum) age, weight, and body mass index (BMI) of 20 ICU patients were 57 (39, 78) years, 65 (48, 106) kg, and 23.3 (16.2, 33.8) kg/m(2), respectively. The average anidulafungin area under the curve over the 24-hour dosing interval (AUC(0-24)), maximum concentration (C-max), and clearance (CL) in 20 ICU patients were 92.7 mg.h/liter, 7.7 mg/liter, and 1.3 liters/h, respectively. The exposure in the 240-kg patient at a daily 150-mg dose was within the range observed in ICU patients overall. The average AUC(0-24) and C-max in the general patient population and healthy subjects were 110.3 and 105.9 mg.h/liter and 7.2 and 7.0 mg/liter, respectively. The pharmacokinetics of anidulafungin in ICU patients appeared to be comparable to those in the general patient population and healthy subjects at the same dosing regimen.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 5
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