Apoptosis regulation in adrenocortical carcinoma

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Pereira, SS (Author) ICBAS; Monteiro, M (Author) ICBAS; Antonin, SR (Author) Other; Pignatelli, D (Author) Other

Journal

Title: Endocrine Connections

Vol. 8

Pages: R91-R104

Publisher: BioScientifica Ltd.

Indexing

ISI Web of Knowledge - 4 Citations

Other information

Authenticus ID: P-00Q-KRZ

DOI: 10.1530/ec-19-0114

Abstract (EN): Apoptosis evading is a hallmark of cancer. Tumor cells are characterized by having an impaired apoptosis signaling, a fact that deregulates the balance between cell death and survival, leading to tumor development, invasion and resistance to treatment. In general, patients with adrenocortical carcinomas (ACC) have an extremely bad prognosis, which is related to disease progression and significant resistance to treatments. In this report, we performed an integrative review about the disruption of apoptosis in ACC that may underlie the characteristic poor prognosis in these patients. Although the apoptosis has been scarcely studied in ACC, the majority of the deregulation phenomena already described are anti-apoptotic. Most importantly, in a near future, targeting apoptosis modulation in ACC patients may become a promising therapeutic.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14