Metabolomic signatures after bariatric surgery - a systematic review

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Vaz, M (Author) Other; Pereira, SS (Author) ICBAS; Monteiro, M (Author) ICBAS

Journal

The Journal is awaiting validation by the Administrative Services.

Title: REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

ISSN: 1389-9155

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00V-SA2

DOI: 10.1007/s11154-021-09695-5

Abstract (EN): Metabolomics emerged as an important tool to gain insights on how the body responds to therapeutic interventions. Bariatric surgery is the most effective treatment for severe obesity and obesity-related co-morbidities. Our aim was to conduct a systematic review of the available data on metabolomics profiles that characterize patients submitted to different bariatric surgery procedures, which could be useful to predict clinical outcomes including weight loss and type 2 diabetes remission. For that, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses - PRISMA guidelines were followed. Data from forty-seven original study reports addressing metabolomics profiles induced by bariatric surgery that met eligibility criteria were compiled and summarized. Amino acids, lipids, energy-related and gut microbiota-related were the metabolite classes most influenced by bariatric surgery. Among these, higher pre-operative levels of specific lipids including phospholipids, long-chain fatty acids and bile acids were associated with post-operative T2D remission. As conclusion, metabolite profiling could become a useful tool to predict long term response to different bariatric surgery procedures, allowing more personalized interventions and improved healthcare resources allocation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17