Interleukin-6, infection and cardiovascular outcomes in acute heart failure: Findings from the EDIFICA registry

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Vasques-Novoa, F (Author) FMUP; Ferriera, JP (Author) FMUP; Marques, P (Author) Other; Neves, JS (Author) FMUP; Vale, C (Author) Other; Ribeirinho-Soares, P (Author) Other; Marques, J (Author) Other; Martins, S (Author) Other; guimaraes, jt (Author) FMUP; Barros, AS (Author) FMUP; Leite-Moreira AF (Author) FMUP; Roncon-Albuquerque R Jr (Author) FMUP; Almeida, J (Author) Other; Bettencourt P (Author) Other; Friões F (Author) FMUP

Journal

Title: Cytokine

Vol. 160

ISSN: 1043-4666

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00X-74X

DOI: 10.1016/j.cyto.2022.156053

Abstract (EN): Aims: Interleukin-6 (IL-6) is upregulated in response to infectious and inflammatory triggers and independently predicts all-cause mortality in acute heart failure (AHF). However, the association of IL-6 with cardiovascular outcomes and its interplay with C-reactive protein and infection, a major precipitating factor in AHF, remains poorly understood.Methods and results: The association between IL-6 and clinical outcomes (180 days) in AHF was evaluated using a cohort of 164 patients from the EDIFICA registry. Median IL-6 levels at admission were 17.4 pg/mL. Patients in the higher admission IL-6 tertile presented with lower blood pressure and more congestion, were diagnosed more frequently with infection, and had a longer hospital stay. Higher IL-6 levels were associated with increased risk of HF rehospitalization (hazard ratio per log2 3.69, 95% confidence interval (CI) 1.26-10.8, p =.017) and the composite of HF rehospitalization or cardiovascular death (hazard ratio per log2 3.50; 95% CI 1.28-9.57; p =.014), independently of major AHF prognosticators, including B-type natriuretic peptide and renal function. However, no independent associations were found for all-cause rehospitalization or mortality. Despite a mod-erate correlation of IL-6 with C-reactive protein (CRP) levels (R = .51), the latter were not associated with clinical outcomes in this population.Conclusions: IL-6 levels associate with higher rate of cardiovascular events in AHF, independently of classical prognosticators and evidence of infection, outperforming CRP as an inflammatory outcome biomarker.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4