Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform

• Type: Another Publication in an International Scientific Journal
• Date: 2022

Authors

Pinto, M (Author) Other; Silva, V (Author) Other; Barreiro, S (Author) Other; Silva, R (Author) Other; Fernando Remiao (Author) FFUP; Fernanda Borges (Author) FCUP; Fernandes, C (Author) Other

Journal

Title: Ageing Research Reviews

Vol. 79

ISSN: 1568-1637

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 42 Citations

Scopus - 46 Citations

Other information

Authenticus ID: P-00W-STR

DOI: 10.1016/j.arr.2022.101658

Abstract (EN): The discovery of effective drugs for the treatment of neurodegenerative disorders (NDs) is a deadlock. Due to their complex etiology and high heterogeneity, progresses in the development of novel NDs therapies have been slow, raising social/economic and medical concerns. Nanotechnology and nanomedicine evolved exponentially in recent years and presented a panoply of tools projected to improve diagnosis and treatment. Drug-loaded nanosystems, particularly nanoparticles (NPs), were successfully used to address numerous drug glitches, such as efficacy, bioavailability and safety. Polymeric nanoparticles (PNPs), mainly based on polylactic-co-glycolic acid (PLGA), have been already validated and approved for the treatment of cancer, neurologic dysfunctions and hormonal-related diseases. Despite promising no PNPs-based therapy for neurodegenerative disorders is available up to date. To stimulate the research in the area the studies performed so far with polylactic-co-glycolic acid (PLGA) nanoparticles as well as the techniques aimed to improve PNPs BBB permeability and drug targeting were revised. Bearing in mind NDs pharmacological therapy landscape huge efforts must be done in finding new therapeutic solutions along with the translation of the most promising results to the clinic, which hopefully will converge in the development of effective drugs in a foreseeable future.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 27