Solid dispersion of praziquantel enhanced solubility and improve the efficacy of the schistosomiasis treatment

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Marques, CSF (Author) Other; Rezende, P (Author) Other; Andrade, LN (Author) Other; Mendes, TMF (Author) Other; Allegretti, SM (Author) Other; Bani, C (Author) Other; Chaud, MV (Author) Other; de Almeida, MB (Author) Other; Souto, EB (Author) Other; da Costa, LP (Author) Other; Severino, P (Author) Other

Journal

Title: Journal of Drug Delivery Science and Technology

Vol. 45

Pages: 124-134

ISSN: 1773-2247

Publisher: Editions de Sante

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 15 Citations

Other information

Authenticus ID: P-00N-XEF

DOI: 10.1016/j.jddst.2018.03.009

Abstract (EN): Praziquantel (PZQ) is an anthelmintic of choice in the treatment of schistosomiasis. Solvent evaporation technique produced three different Solid Dispersions (SD) (drug: polymer, w/w) with sodium alginate (ALG) or carboxymethylcellulose (CMC). Characterization was done by X-Ray Diffraction (XRD), Fourier Transformed Infrared spectroscopy (FTIR) and Scanning Electron Microscopy (SEM), thermal analysis (DSC/TG), cell viability and in vitro assay against S. mansoni. The results of SD with different ratios revealed that the 1:0.25 ratio of PZQ with ALG showed higher solubility. The morphological structure change to the lamellar structure that it was confirmed with XRD. Then, thermal analyses and FTIR indicating a significant interaction between PZQ and polymer in SD indicate a change in the molecular mobility of the drug. In a culture of S. mansoni, we observed that SD is leading the death of the parasites. Regarding cytotoxicity, SD does not show toxicity in fibroblasts cells.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11