Uveal melanoma: physiopathology and new in situ-specific therapies

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Souto, EB (Author) Other; Zielinska, A (Author) Other; Luis, M (Author) Other; Carbone, C (Author) Other; Martins Gomes, C (Author) Other; Souto, SB (Author) Other; Silva, AM (Author) Other

Journal

Title: Cancer Chemotherapy and Pharmacology

Vol. 84

Pages: 15-32

ISSN: 0344-5704

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 24 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00Q-MAE

DOI: 10.1007/s00280-019-03860-z

Abstract (EN): Uveal melanoma is the most common primary intraocular tumor in adults. It can arise from melanocytes in the anterior (iris) or posterior uveal tract (choroid and ciliary body). Uveal melanoma has a particular molecular pathogenesis, being characterized by specific chromosome alterations and gene mutations (e.g., GNAQ/GNA11; BAP1), which are considered promising targets for molecular therapy. Primary treatment of uveal melanoma includes radiotherapy (brachytherapy and charged-particle therapy), phototherapy (photocoagulation, transpupillary thermal therapy, and photodynamic therapy) and surgery (local resection, enucleation and exenteration). Approximately half of patients with uveal melanoma will, however, develop metastasis, especially in the liver. The treatment of metastatic uveal melanoma includes systemic chemotherapy, immunotherapy and molecular targeted therapy. Liver-directed therapies, such as resection, chemoembolization, immunoembolization, radioembolization, isolated hepatic perfusion and percutaneous hepatic perfusion, are also available to treat metastatic uveal melanoma. Several clinical trials are being developed to study new therapeutic options to treat uveal melanoma, mainly for those with identified liver metastases. The present work discusses the physiopathology and new in situ-specific therapies for the treatment of uveal melanoma.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18