SLN and NLC for topical, dermal, and transdermal drug delivery

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Souto, EB (Author) Other; Baldim, I (Author) Other; Oliveira, WP (Author) Other; Rao, RH (Author) Other; Yadav, N (Author) Other; Gama, FM (Author) Other; Mahant, S (Author) Other

Journal

Title: Expert Opinion on Drug Delivery

Vol. 17

Pages: 357-377

ISSN: 1742-5247

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 15 Citations

Scopus - 45 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00R-RZQ

DOI: 10.1080/17425247.2020.1727883

Abstract (EN): Introduction: From a biopharmaceutical standpoint, the skin is recognized as an interesting route for drug delivery. In general, small molecules are able to penetrate the stratum corneum, the outermost layer of the skin. In contrast, the delivery of larger molecules, such as peptides and proteins, remains a challenge. Nanoparticles have been exploited not only to enhance skin penetration of drugs but also to expand the range of molecules to be clinically used. Areas covered: This review focus on Solid lipid nanoparticles (SLN) and Nanostructured lipid carriers (NLC) for skin administration. We discuss the selection criteria for lipids, surfactants, and surface modifiers commonly in use in SLN/NLC, their production techniques, and the range of drugs loaded in these lipid nanoparticles for the treatment of skin disorders. Expert opinion: Depending on the lipid and surfactant composition, different nanoparticle morphologies can be generated. Both SLN and NLC are composed of lipids that resemble those of the skin and sebum, which contribute to their enhanced biocompatibility, with limited toxicological risk. SLN and NLC can be loaded with very chemically different drugs, may provide a tunable release profile, can be produced in a sterilized environment, and be scaled-up without the need for organic solvents.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 21