Therapeutic Approaches for Age-Related Macular Degeneration

• Type: Another Publication in an International Scientific Journal
• Date: 2022

Authors

Galindo-Camacho, RM (Author) Other; Blanco-Llamero, C (Author) Other; da Ana, R (Author) Other; Fuertes, MA (Author) Other; Senorans, FJ (Author) Other; Silva, AM (Author) Other; Garcia, ML (Author) Other; Souto, EB (Author) FFUP

Journal

Title: International Journal Of Molecular Sciences

Vol. 23

ISSN: 1661-6596

Publisher: MDPI

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 12 Citations

Other information

Authenticus ID: P-00X-BS9

DOI: 10.3390/ijms231911769

Abstract (EN): Damage to the retinal pigment epithelium, Bruch's membrane and/or tissues underlying macula is known to increase the risk of age-related macular degeneration (AMD). AMD is commonly categorized in two distinct types, namely, the nonexudative (dry form) and the exudative (wet form). Currently, there is no ideal treatment available for AMD. Recommended standard treatments are based on the use of vascular endothelial growth factor (VEGF), with the disadvantage of requiring repeated intravitreal injections which hinder patient's compliance to the therapy. In recent years, several synthetic and natural active compounds have been proposed as innovative therapeutic strategies against this disease. There is a growing interest in the development of formulations based on nanotechnology because of its important role in the management of posterior eye segment disorders, without the use of intravitreal injections, and furthermore, with the potential to prolong drug release and thus reduce adverse effects. In the same way, 3D bioprinting constitutes an alternative to regeneration therapies for the human retina to restore its functions. The application of 3D bioprinting may change the current and future perspectives of the treatment of patients with AMD, especially those who do not respond to conventional treatment. To monitor the progress of AMD treatment and disease, retinal images are used. In this work, we revised the recent challenges encountered in the treatment of different forms of AMD, innovative nanoformulations, 3D bioprinting, and techniques to monitor the progress.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 24