Customized cationic nanoemulsions loading triamcinolone acetonide for corneal neovascularization secondary to inflammatory processes

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Fernandes, AR (Author) Other; Vidal, LB (Author) Other; Sanchez Lopez, E (Author) Other; dos Santos, T (Author) Other; Granja, PL (Author) Other; Silva, AM (Author) Other; Garcia, ML (Author) Other; Souto, EB (Author) FFUP

Journal

Title: International Journal of Pharmaceutics

Vol. 623

ISSN: 0378-5173

Publisher: Elsevier

Indexing

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Other information

Authenticus ID: P-00W-SV4

DOI: 10.1016/j.ijpharm.2022.121938

Abstract (EN): Customized cationic oil-in-water nanoemulsions (NEs) have been produced to improve the bioavailability of poorly water-soluble drugs, such as triamcinolone acetonide (TA). TA is a synthetic glucocorticoid with antiinflammatory and antiangiogenic therapeutic properties and it is widely used as an effective treatment in ocular disorders. In this work, TA-NEs were characterized using two different custom-made cationic surfactants, showing a high positive surface charge favouring corneal penetration and a particle size below 300 nm. Both TANE formulations demonstrated to be stable at 4 degrees C during the first months of storage. Furthermore, TA-NEs were able to produce antiangiogenic effects in chicken membranes. The TA-NEs safety profile was evaluated using in vitro and in vivo ocular tolerance tests. Out of the two formulations, the one showing no irritant effects was screened in vivo demonstrating capacity to ameliorate ocular inflammation in New Zealand rabbits significantly, specially to reduce the risk of ocular inflammation processes, with antiangiogenic activity, and can therefore be exploited as a suitable formulation to avoid inflammatory reactions upon ocular surgical procedures, such as cataracts.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14