The role of spray-drying atmosphere on fridericia chica (bonpl.) LG Lohmann standardized extract production for wound healing activity

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Sousa, IMD (Author) Other; Rivera, GA (Author) Other; Pinto, D (Author) Other; Queiroz, NDA (Author) Other; Bastos, VIC (Author) Other; Braga, LEO (Author) Other; Palmeira, JD (Author) Other; Amaral, H (Author) Other; Helena Sousa (Author) FFUP; Oliveira, HCC (Author) Other; Goncalves, FJM (Author) Other; Ruiz, ALTG (Author) Other; Ibanez, E (Author) Other; Beatriz B P P Oliveira (Author) FFUP; Foglio, MA (Author) Other

Journal

Title: Natural Product Research

Pages: 1-5

ISSN: 1478-6419

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00V-W6D

DOI: 10.1080/14786419.2021.2012773

Abstract (EN): Fridericia chica (Bonpl.) L.G. Lohmann (synonym Arrabidaea chica Verlot) is widely used in Brazilian folk medicine. Considering overcoming pitfalls of scaling up production of plant extracts, herein the effects of N-2 atmosphere for extract spray-drying process is reported. Samples were monitored by in vitro antioxidant activity and microbiological evaluation. The drying atmosphere influenced 3-deoxyanthocyanines content when using air as atomizing gas, decreasing carajurin (37.5%) content with concomitant increase in luteolin yield (24.1%). Both drying processes preserved the pharmacological activity. In the cell migration test with HaCaT cells, the extract dried under air flow (5 mu g/mL) promoted wound closure by 78% (12 hours) whereas the extract dried using N-2 flow promoted 49% (12 hours), with 98% closure (12 hours) for the positive control. The antimicrobial evaluation for Staphylococcus aureus did not differ within drying atmospheres, with MIC (minimum inhibitory concentration) at 0.39 mg/mL. Therefore, the drying process reported herein did not interfere with the biological activity's outcome.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5