Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Pereira, D (Author) Other; Pinto, M (Author) Other; Marta Correia da Silva (Author) FFUP; Honorina Cidade (Author) FFUP

Journal

Title: Molecules

Serial No. 3 Vol. 27 No. 969

Final page: 230

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 35 Citations

Scopus - 34 Citations

Other information

Authenticus ID: P-00V-YRC

DOI: 10.3390/molecules27010230

Abstract (EN): As a result of the biological activities of natural flavonoids, several synthetic strategies aiming to obtain analogues with improved potency and/or pharmacokinetic profile have been developed. Since the triazole ring has been associated with several biological activities and metabolic stability, hybridization with a 1,2,3-triazole ring has been increasingly reported over the last years. The feasible synthesis through copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) has allowed the accomplishment of several hybrids. Since 2017, almost 700 flavonoid hybrids conjugated with 1,2,3-triazole, including chalcones, flavones, flavanones and flavonols, among others, with antitumor, antimicrobial, antidiabetic, neuroprotective, anti-inflammatory, antioxidant, and antifouling activity have been reported. This review compiles the biological activities recently described for these hybrids, highlighting the mechanism of action and structure-activity relationship (SAR) studies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 43