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Neurotoxicity of psychoactive substances: A mechanistic overview

Title
Neurotoxicity of psychoactive substances: A mechanistic overview
Type
Article in International Scientific Journal
Year
2021
Authors
da Silva, DD
(Author)
Other
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Silva, JP
(Author)
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Felix Carvalho
(Author)
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Journal
The Journal is awaiting validation by the Administrative Services.
Vol. 28
Pages: 76-83
ISSN: 2468-2020
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Publicação em ISI Web of Knowledge ISI Web of Knowledge - 0 Citations
Publicação em Scopus Scopus - 0 Citations
Other information
Authenticus ID: P-00V-JGV
Abstract (EN): The increasing abuse of psychoactive drugs represents a global public health burden, as recurrent exposure to these substances can cause neurodegeneration, premature ageing and negatively impact normal neurodevelopment. Although the basis of such neurotoxic effects is not completely elucidated, compelling evidence has shown that dysregulation of neurotransmission, disruption of mitochondrial function and dynamics, overproduction of ROS, impairment of neuro-immunomodulation, and epigenetic alterations are caused by many psychoactive substances (e.g., alcohol, cannabinoids, opioids, amphetamines and cocaine). Understanding the neurotoxicological profiles of psychoactive substances and the underlying pathways assumes major importance towards reaching improved risk assessment and treatment of drug use disorders. As such, we herein reviewed the most recent up -dates on the respective drug-induced cellular and molecular mechanisms.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 8
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