Drugs of abuse and kidney toxicity

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Silva, JP (Author) Other; Helena Carmo (Author) FFUP; Felix Carvalho (Author) FFUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: CURRENT OPINION IN TOXICOLOGY

Vol. 32

ISSN: 2468-2020

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00W-Y61

DOI: 10.1016/j.cotox.2022.100360

Abstract (EN): The increasing consumption of drugs of abuse represents a global public health concern. Kidneys are especially vulnerable to the toxic effects of these substances, as these organs are involved in their filtration, concentration and metabolism to potentially toxic metabolites. Distinct clinical manifestations known to precede acute and chronic kidney injury (e.g., rhabdomyolysis, vasoconstriction, decreased estimated glomerular filtration rate) have been reported for different drugs of abuse (e.g., cannabinoids, cocaine, opioids, substituted phenethylamines). However, the underlying mechanisms remain poorly understood. As such, we herein review the most recent updates on the nephrotoxicity associated with drugs of abuse, as understanding their nephrotoxic profile assumes major relevance to improve risk assessment and therapeutic responses to drug-related complications.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7