Investigation of the factors influencing the incorporation of clotrimazole in SLN and NLC prepared by hot high-pressure homogenization

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Souto, EB (Author) Other; Mueller, RH (Author) Other

Journal

Title: Journal of Microencapsulation

Vol. 23

Pages: 377-388

ISSN: 0265-2048

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 81 Citations

Scopus - 109 Citations

Other information

Authenticus ID: P-00F-SBQ

DOI: 10.1080/02652040500435295

Abstract (EN): Clotrimazole, a fungicidal effective for the local treatment of cutaneous and mucosal infections, was incorporated into solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). The aim was to increase its dermal bioavailability and to control drug release, thereby potentially reducing its side effects. Prior to the release studies, the carrier was optimized and characterized by using different techniques. Laser diffractometry (LD), photon correlation spectroscopy (PCS) and scanning electron microscopy (SEM) indicated that SLN were spherical in shape with a mean size of similar to 400nm. Some aggregation phenomena occurred during preparation of SEM samples due to the lipid character of the carriers. No physico-chemical instability of the drug-loaded lipid nanoparticles was detected during 2 years of storage at different temperatures. X-ray and DSC results suggested that during storage time the drug remained molecularly dispersed in the lipid matrix. Drug associated to SLN and NLC in its crystal form could be excluded.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12