A Note on Regulatory Concerns and Toxicity Assessment in Lipid-Based Delivery Systems (LDS)

• Type: Another Publication in an International Scientific Journal
• Date: 2009

Authors

Souto, EB (Author) Other; Martins Lopes, P (Author) Other; Lopes, CM (Author) Other; Gaivao, I (Author) Other; Silva, AM (Author) Other; Guedes Pinto, H (Author) Other

Journal

Title: Journal of Biomedical Nanotechnology

Vol. 5

Pages: 317-322

ISSN: 1550-7033

Publisher: American Scientific Publishers

Indexing

ISI Web of Knowledge - 23 Citations

Scopus - 28 Citations

Other information

Authenticus ID: P-003-H3Z

DOI: 10.1166/jbn.2009.1041

Abstract (EN): Lipid-based Delivery Systems (LDS) has been the focus of potential strategies in drug delivery for several years. A great deal of work has been invested on how to exploit their biocompatible and biodegradable nature, in combination with their nanosize range in a profitable way in the field of nanomedicines. A number of drugs loaded in LDS have been already tested in vivo successfully. However, in vivo behaviour of nanosized materials differs from their bulk counterparts (and also change drug properties), mainly depending on the particular LDS physicochemical characteristics. These may have huge impact on the toxicity of the system, despite the physiological nature of the lipid materials. This note on the regulatory concerns and toxicity assessment in LDS suggests that current knowledge of public and scientific communities is lacking, requiring intensive research and policy measures to provide a deep understanding on toxicological risks.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6