Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers - A systematic review of in vitro data

• Type: Another Publication in an International Scientific Journal
• Date: 2014

Authors

Doktorovova, S (Author) Other; Souto, EB (Author) Other; Silva, AM (Author) Other

Journal

Title: European Journal of Pharmaceutics and Biopharmaceutics

Vol. 87

Pages: 1-18

ISSN: 0939-6411

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 301 Citations

Scopus - 237 Citations

Other information

Authenticus ID: P-009-GVV

DOI: 10.1016/j.ejpb.2014.02.005

Abstract (EN): Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were developed as alternative to other colloidal carriers. They were designed to overcome lipid nanoemulsions and liposomes in stability and ability to control the release of an encapsulated substance, and at the same time to be better tolerated than polymeric nanoparticles. Since the patenting of SLN discovery, large amount of data became available on the behaviour of these systems in vitro. SLN/NLC have many prerequisites to be a well tolerated carrier - the currently available data seem to confirm it, but there are also some contradictory results. In this review, we collected the available data from cytotoxicity, oxidative stress and hemocompatibility studies in vitro and analysed their outcomes. We also provide a summary of the available data in a form of reference table.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18