Modulation of neuronal activity and hepatic metabolism by ploidy and L-carnitine supplement in rainbow trout (Oncorhynchus mykiss)

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Nunes, B (Author) Other; Miranda, AF (Author) Other; Ozorio, ROA (Author) Other; Goncalves, F (Author) Other; goncalves, j (Author) ICBAS; Correia, AT (Author) Other

Journal

Title: Aquaculture Nutrition

Vol. 20

Pages: 242-252

ISSN: 1353-5773

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-009-GQG

DOI: 10.1111/anu.12070

Abstract (EN): l-carnitine, a multiphysiological, bioactive and pollution-free additive, is known to act as a growth-enhancer and appears to act as an antioxidant compound. However, high dosages may cause detrimental physiological effects to fish. Considering such, a feeding trial was carried out to evaluate the effects of dietary l-carnitine content on neuronal activity (acetylcholinesterasic activity), hepatic metabolism (catalase activity) and liver histological markers in both diploid and triploid trout (Oncorhynchus mykiss) juveniles. Fish were hand-fed for 56days on three nutritionally identical diets, varying in l-carnitine content; unsupplemented diet (15mgkg(-1)) and supplemented (200 or 530mg kg(-1)) diets. Moderate to severe glycogen/lipid depletion was the major liver histopathological disorder observed in all dietary groups. This cause-effect relationship appeared to be dose and time-dependent, suggesting an important role of l-carnitine in the liver metabolism. Moreover, the hepatocite size and nuclear diameter appeared to be larger in l-carnitine supplemented groups than in control group. l-carnitine caused significant induction of catalase activity and inhibition of AChE. Diploid and triploid trouts showed marked differences in enzymatic activities, reflected by consistently higher values of AChE activities for triploid animals.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11