Valorization of Kiwiberry Leaves Recovered by Ultrasound-Assisted Extraction for Skin Application: A Response Surface Methodology Approach

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Silva, AM (Author) Other; Pinto, D (Author) Other; Moreira, MM (Author) Other; Paulo Costa (Author) FFUP; Delerue-Matos, C (Author) Other; Rodrigues, F (Author) Other

Journal

Title: Antioxidants

Vol. 396

Final page: 763

ISSN: 2076-3921

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00W-FCW

DOI: 10.3390/antiox11040763

Abstract (EN): This study aims to evaluate the optimal ultrasound-assisted extraction (UAE) conditions of antioxidants polyphenols from Actinidia arguta (Siebold & Zucc.) Planch. Ex Miq. (kiwiberry) leaves using a response surface methodology (RSM). The effects of solid:liquid ratio (2.5-10.0% w/v), time (20-60 min), and intensity (30-70 W/m(2)) on the total phenolic content (TPC) and antioxidant/antiradical activities were investigated. The optimal UAE conditions were achieved using a solid:liquid ratio of 10% (w/v) and an ultrasonic intensity of 30 W/m(2) for 31.11 min. The results demonstrated that the optimal extract showed a high TPC (97.50 mg of gallic acid equivalents (GAE)/g dw) and antioxidant/antiradical activity (IC50 = 249.46 mu g/mL for ABTS assay; IC50 = 547.34 mu g/mL for DPPH assay; 1440.13 mu mol of ferrous sulfate equivalents (FSE)/g dw for ferric reducing antioxidant power (FRAP)) as well as a good capacity to scavenge superoxide and hypochlorous acid (respectively, IC50 = 220.13 mu g/mL and IC50 =10.26 mu g/mL), which may be related with the 28 phenolic compounds quantified. The in vitro cell assay demonstrated that the optimal extract did not decrease the keratinocytes' (HaCaT) viability, while the fibroblasts' (HFF-1) viability was greater than 70.63% (1000 mu g/mL). This study emphasizes the great potential of kiwiberry leaves extracted by UAE for skin application.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15