Histological and scanning electron microscopy analyses of bone/implant interface using the novel bonelikee synthetic bone graft

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Gutierres, M (Author) FMUP; Hussain, NS (Author) Other; Lopes, MA (Author) FEUP; Américo Afonso (Author) FMDUP; Cabral, AT (Author) Other; Almeida, L (Author) Other; Santos, JD (Author) FEUP

Journal

Title: Journal of Orthopaedic Research

Vol. 24

Pages: 953-958

ISSN: 0736-0266

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 20 Citations

ISI Web of Science

Scopus - 21 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-004-M13

DOI: 10.1002/jor.20117

Abstract (EN): Synthetic bone grafts provide an alternative to autografts and allografts. Bonelike (R) is a patented synthetic bone graft that mimics the mineral composition of bone. The aim of the present work was to assess the biological behavior of Bonelike (R)(g) graft in humans, before using the material in orthopedic applications of bone regeneration, for example, in opening wedge high tibial osteotornies for medial knee osteoarthritis. Bonelike (R) granules were implanted in cortical bone of 11 patients undergoing osteotornies, and new bone formation, osteoconductive proper-ties, and resorption characteristics of the granules were analyzed. The granules ranged from 500 to 1000 mu m and were implanted in the lateral aspect of the tibia. The patients' mean age was 59 years (range 48 to 70 years); there were eight women and three men, all suffering from medial compartment osteoarthritis of the knee. At surgery, a 1 x 1 x 1-cm cortical defect was created 3 cm distal to the entry point of the screws, in line with the long axis of tibia. The implanted Bonelike (R) graft sample was extracted for analysis during removal of the metallic prosthesis after implantation times of 6, 9, and 12 months. Radiological follow-up,. scanning electron microscopy, histological analysis, and histomorphometric measurements were conducted on the retrieved samples to assess bone regeneration in the defect area. Osteoconductive capacity was demonstrated by extensive mature bone formation around the implanted granules and high levels of percentage bone-to-graft contact (from 67-84%). Bonelike (R) acted as an excellent bioactive scaffold, allowing the migration, proliferation, and differentiation of bone cells on its surface, and therefore regeneration of the defects was achieved in a rapid, controlled manner. Our results suggest that Bonelike (R) graft is an excellent candidate for orthopedic applications where rapid new bone formation is a fundamental requirement. (c) 2006 Orthopaeclic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 24:953-958, 2006.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6