IL-10 Overexpression After BCG Vaccination Does Not Impair Control of Mycobacterium tuberculosis Infection

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Ferreira, CM (Author) Other; Micheli, C (Author) Other; Barreira-Silva, P (Author) Other; Barbosa, AM (Author) Other; Resende, M (Author) Other; Manuel Vilanova (Author) ICBAS; Silvestre, R (Author) Other; Cunha, C (Author) Other; Carvalho, A (Author) Other; Rodrigues, F (Author) Other; Correia-Neves, M (Author) Other; Castro, AG (Author) Other; Torrado, E (Author) Other

Journal

Title: Frontiers In Immunology

Vol. 13

ISSN: 1664-3224

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge - 0 Citations

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Other information

Authenticus ID: P-00X-10M

DOI: 10.3389/fimmu.2022.946181

Abstract (EN): Control of tuberculosis depends on the rapid expression of protective CD4(+) T-cell responses in the Mycobacterium tuberculosis (Mtb)-infected lungs. We have recently shown that the immunomodulatory cytokine IL-10 acts intrinsically in CD4(+) T cells and impairs their parenchymal migratory capacity, thereby preventing control of Mtb infection. Herein, we show that IL-10 overexpression does not impact the protection conferred by the established memory CD4(+) T-cell response, as BCG-vaccinated mice overexpressing IL-10 only during Mtb infection display an accelerated, BCG-induced, Ag85b-specific CD4(+) T-cell response and control Mtb infection. However, IL-10 inhibits the migration of recently activated ESAT-6-specific CD4(+) T cells into the lung parenchyma and impairs the development of ectopic lymphoid structures associated with reduced expression of the chemokine receptors CXCR5 and CCR7. Together, our data support a role for BCG vaccination in preventing the immunosuppressive effects of IL-10 in the fast progression of Mtb infection and may provide valuable insights on the mechanisms contributing to the variable efficacy of BCG vaccination.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11