Nano-based drug delivery systems used as vehicles to enhance polyphenols therapeutic effect for diabetes mellitus treatment

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Rocha, S (Author) Other; Lucas, M (Author) Other; Ribeiro, D (Author) Other; Corvo, ML (Author) Other; Eduarda Fernandes (Author) FFUP; Freitas, M (Author) Other

Journal

Title: Pharmacological Research

Vol. 169

ISSN: 1043-6618

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00T-X9E

DOI: 10.1016/j.phrs.2021.105604

Abstract (EN): Diabetes mellitus is one of the biggest health emergencies of the 21st century worldwide, characterized by deficiency in insulin secretion and/or action, leading to hyperglycemia. Despite the currently available antidiabetic therapeutic options, 4.2 million people died in 2019 due to diabetes. Thus, new effective interventions are required. Polyphenols are plant secondary metabolites and have been recognized for their vast number of biological activities, including potential antidiabetic effects. However, the poor bioavailability and high metabolization of polyphenols restrict their biological effects in vivo. Nanotechnology is a promising area of research to improve the therapeutic effect of several compounds. Therefore, this review provides an overview of the literature about the utility of nano-based drug delivery systems as vehicles of polyphenols in diabetes treatment. It was possible to conclude that, in general, nano-based drug delivery systems can potentiate the beneficial antidiabetic properties of polyphenols, when compared with the free compounds, opening a new field of research in diabetology.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 25