Long-Term Effect of Anti-Vascular Endothelial Growth Factor (Anti-VEGF) Injections in Choroidal Neovascularization Secondary to Angioid Streaks

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Torres Costa, S (Author) Other; Bernardes, J (Author) Other; Mano, SS (Author) Other; Medeiros Pinto, J (Author) Other; Abreu, AC (Author) Other; Furtado, MJ (Author) Other; Silva, R (Author) Other; Marques Neves, C (Author) Other; Falcão-Reis F (Author) FMUP; Ângela Carneiro (Author) FMUP; Colaco, L (Author) Other; Manuel Falcão (Author) FMUP

Journal

Title: Journal of Ophthalmology

Vol. 2022

Pages: 1-7

ISSN: 2090-004X

Publisher: Hindawi

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00W-YSB

DOI: 10.1155/2022/3332421

Abstract (EN): Purpose. This study aimed to evaluate the long-term effectiveness of intravitreal anti-vascular endothelial growth factor (VEGF) injections in the treatment of choroidal neovascularization (CNV) associated with angioid streaks. Methods. Multicenter retrospective cohort study, including eyes with CNV secondary to angioid streaks treated with anti-VEGF injections, were performed. Best-corrected visual acuity (BCVA) in ETDRS letters; qualitative and quantitative (foveal thickness) OCT parameters; anti-VEGF type; and number of injections were collected at baseline and at 3, 6, 12, 24, 36, 48, 60, and 72 months. Results. Thirty-nine eyes from 29 patients, 17 (58.6%) females, were included. The mean follow-up time was 69.4 +/- 34.5 months. BCVA was 59.3 +/- 23.3 letters at baseline and 63.7 +/- 21.9 letters at 48 months. At 3 months, BCVA improved 6.9 +/- 11.7 letters (P=0.003). Then, BCVA remained stable. The mean foveal thickness decreased from 343.3 +/- 120.2 mu m at baseline to 268.3 +/- 65.4 at 48 months (P=0.021). The mean number of injections was 4.6 +/- 2.1 at 12 months, decreasing to 1.7 +/- 2.4 injections between 36 and 48 months (P=0.093). Conclusion. This real-world study suggests that the functional and morphologic response to anti-VEGF therapy for CNV related to angioid streaks is generally satisfactory and maintained in the long term.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7