Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Gouveia, MJ (Author) Other; Santos, J (Author) Other; Brindley, PJ (Author) Other; Rinaldi, G (Author) Other; Lopes, C (Author) Other; Santos, LL (Author) Other; Correia da Costa, JMC (Author) Other; Nuno Vale (Author) FCUP

Journal

Title: Cancer Letters

Vol. 359

Pages: 226-232

ISSN: 0304-3835

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 40 Citations

Scopus - 43 Citations

Other information

Authenticus ID: P-00A-6KF

DOI: 10.1016/j.canlet.2015.01.018

Abstract (EN): An estrogen-DNA adduct mediated pathway may be involved in the pathogenesis of the squamous cell carcinoma of the bladder associated with infection with the blood fluke Schistosoma haematobium. Extracts from developmental stages of S. haematobium, including eggs, induce tumor-like phenotypes in cultured cells. In addition, estrogen-derived, reactive metabolites occur in this pathogen and in sera of infected persons. Liquid chromatography-mass spectrometry analysis was performed on urine from 40 Angolans diagnosed with urogenital schistosomiasis (UGS), half of who also presented UGS-associated squamous cell carcinoma and/or urothelial cell carcinoma. The analysis revealed numerous estrogenlike metabolites, including seven specifically identified in UGS cases, but not reported in the database of metabolites in urine of healthy humans. These schistosome infection-associated metabolites included catechol estrogen quinones (CEQ) and CEQ-DNA-adducts, two of which had been identified previously in S. haematobium. In addition, novel metabolites derived directly from 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodG) were identified in urine of all 40 cases of UGS. These metabolites can be expected to provide deeper insights into the carcinogenesis UGS-induced bladder cancer, and as biomarkers for diagnosis and/or prognosis of this neglected tropical disease-linked cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7